Our meta-analysis suggests that weight loss may be a risk factor for hip fracture and that weight gain may be a protective factor for hip fracture.įracture has increasingly become a main cause of morbidity in the population as well as a significant global health concern 1, 2. For weight gain and risk of hip fracture, the descending curve below the line of RR = 1 this trend is consistent with the results of forest plots that examine weight gain and hip fracture.
Dose-response meta-analysis shows that the risk of hip fracture is an ascending curve, with an increase of weight loss above the line of RR = 1 this trend is consistent with the results of forest plots that examine weight loss and hip fracture. In contrast, weight gain can decrease the risk of hip fracture, with an adjusted RR (95% CI) of 0.73 (0.61, 0.89). Weight loss is more likely a risk factor of hip fracture, with an adjusted RR (Relative Risk) (95% CI) of 1.84 (1.45, 2.33).
The weight loss studies included 85592 participants with 1374 hip fractures and the weight gain studies included 80768 participants with 732 hip fractures. We searched PubMed and Embase for studies on weight change and risk of hip fracture. The relationship between weight change and risk of hip fracture is still controversial.
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